Dr Yannis Alexandrides: The Surgical Innovator Behind 111SKIN and the Future of Aesthetic Science
Luxury skincare has become a rapidly evolving industry, yet few brands possess the scientific credibility, surgical expertise, and clinical heritage that define 111SKIN. At the centre of this global success is Dr Yannis Alexandrides, a triple board-certified plastic and reconstructive surgeon whose work bridges the gap between advanced medical science and high-performance cosmetic skincare.
With more than three decades of surgical experience, groundbreaking research, and a global aesthetic empire, Dr Alexandrides represents a rare combination of clinical mastery and innovative entrepreneurship. His London-based clinic, 111 Harley St., is widely recognised as one of the most respected centres for facial aesthetics, while his luxury brand 111SKIN has become a world leader in scientifically formulated skincare.
The Journey of Dr Yannis Alexandrides – From Medical Scholar to Global Authority
Early Academic Excellence and Medical Foundations
Born with a strong desire to serve medicine at the highest level, Dr Yannis Alexandrides pursued an intensive academic journey beginning at the Athens University School of Medicine in Greece. Graduating with honours, he distinguished himself early through research on oncogenes, progesterone receptors, and DNA markers associated with cancer prognosis.
This scientific foundation shaped his analytical approach to surgery and later became integral to the formulation philosophy behind 111SKIN.
Advanced Surgical Training in the United States
Dr Alexandrides expanded his medical expertise through some of the most competitive surgical programmes in the United States. His training path included:
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General and Plastic Surgery Residency at Temple University, Albert Einstein Medical Centre
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Craniofacial and Microsurgery Fellowship at the University of Pittsburgh Medical Center
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Plastic and Reconstructive Surgery Residency at the University of Miami–Jackson Memorial Hospital
These experiences exposed him to cutting-edge surgical innovations, complex reconstructive cases, and the advanced medical systems that shaped his surgical philosophy.
Establishing 111 Harley St. – A London Landmark for Aesthetic Excellence
Founding One of the UK’s Premier Plastic Surgery Clinics
In 2001, Dr Alexandrides established 111 Harley St. in London, positioned at the centre of the world’s most distinguished medical district. Over two decades later, the clinic remains a leading global destination for patients seeking surgical excellence, innovation, and natural-looking results.
His reputation is particularly strong in rhinoplasty, facelift surgery, and precision-driven aesthetic procedures. As Medical Director, Dr Alexandrides has continuously elevated the clinic’s offerings through new technologies, treatment protocols, and research-led approaches.
Commitment to Safety, Innovation, and Individualised Care
The clinic’s philosophy revolves around patient-centred care, medical precision, and continual improvement. Driven by Dr Alexandrides’ dedication to excellence, 111 Harley St. integrates:
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State-of-the-art surgical technology
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Highly specialised treatment pathways
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Multi-disciplinary expertise
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Evidence-based procedural techniques
It is this commitment to superior outcomes that inspired the development of the skincare brand 111SKIN.
111SKIN – Surgically Inspired Skincare Backed by Scientific Innovation
H3: The Birth of 111SKIN Through Clinical Necessity
The origins of 111SKIN came from a genuine clinical need. During his surgical practice, Dr Alexandrides searched for products that would accelerate healing, protect post-surgical skin, and enhance results. When existing solutions were insufficient, he collaborated with leading scientists to develop a formula capable of supporting the skin’s natural recovery process.
This eventually led to the creation of the now-iconic NAC Y²™ complex, a powerful combination of antioxidants and reparative ingredients that became the foundation of the first 111SKIN product.
Evolution into a Global Luxury Skincare Brand
From one formula used exclusively for his patients, 111SKIN expanded into a full luxury skincare line recognised worldwide. Today, the brand is known for:
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Surgically precise formulations
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High-grade ingredients
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Visible, clinical-level results
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A strong scientific identity
The guiding philosophy remains consistent: every product must deliver targeted, measurable improvements that mirror the precision of surgical care.
The Scientific Approach Behind 111SKIN
111SKIN focuses on advanced research, bioactive complexes, and innovative ingredient technologies. Each product undergoes rigorous testing inspired by medical standards developed at 111 Harley St.
Key attributes include:
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Scientifically engineered formulas
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Multi-active ingredient systems
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Long-term visible improvements
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Luxurious textures and sensorial experience
This combination of clinical science and luxury formulation sets the brand apart in a highly competitive market.
The Expanding 111 Aesthetic Family
111SPA/CLINIC – A Revolutionary Spa Concept
Beyond surgical practice and skincare, Dr Alexandrides broadened his aesthetic universe with 111SPA/CLINIC, an advanced spa concept delivering performance-based face and body treatments. The spa blends cutting-edge technology with multi-sensory experiences, offering:
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High-performance facials
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Body sculpting and rejuvenation treatments
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Specialist skincare protocols featuring 111SKIN products
This dynamic blend of relaxation and clinical-grade results makes the spa concept unique in the global wellness industry.
111CRYO/HEAT – Biohacking for Optimal Wellness
Further expanding his footprint in the wellness sector, Dr Alexandrides launched 111CRYO/HEAT, a biohacking clinic specialising in innovative temperature and light therapies. Treatments such as cryotherapy, thermotherapy, and targeted light exposure help optimise:
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Recovery
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Circulation
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Cellular performance
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Immune response
This venture reinforces Dr Alexandrides’ focus on holistic wellbeing and scientific innovation.
The Impact of Dr Yannis Alexandrides on Modern Aesthetic Medicine
A Leader in Surgical and Non-Surgical Innovation
With more than 30 years of experience, Dr Yannis Alexandrides has become one of the world’s most respected authorities in plastic and reconstructive surgery. His career demonstrates:
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Dedication to precision
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A passion for research
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An ability to translate medical science into luxury consumer products
A Legacy Rooted in Science, Compassion, and Vision
Through his clinic, skincare brand, spa concepts, and biohacking innovations, Dr Alexandrides has created an integrated aesthetic ecosystem unlike any other. His work supports patients not only surgically, but also emotionally, physically, and holistically.
Conclusion: The Future of 111SKIN and the Continuing Legacy of Dr Yannis Alexandrides
From a young medical scholar to a globally recognised surgeon and founder of an international luxury brand, Dr Yannis Alexandrides embodies the perfect fusion of science, artistry, and innovation. His commitment to excellence revolutionised aesthetic medicine, while 111SKIN redefined what luxury skincare can achieve.
As the brand continues to expand and advance, Dr Alexandrides’ influence remains at the forefront—guiding the future of beauty, wellness, and clinical skincare.
